新药研发和配方

通过更加深入地了解蛋白质、抗体或大分子复合物在溶液中的复杂形状信息,从而加速您的药物研发过程,同时也适用于柔性和无序的蛋白质。

生物小角技术是提高您药物配方研究的有利工具,从而可获得宝贵的开发时间:

  • 有关现配的浓缩和稀释溶液中蛋白质相互作用的信息
  • 对低聚反应的高灵敏度
  • 可提高长期稳定性预测的构象和结构变化信息

监测并比较脂质药物传递系统在原料,挤压脂质体和药物产品的相变。

实验室SEC-SAXS联用可用于复杂样品的结构研究

在本应用实例中,通过在线凝胶过滤获得了足够高质量的SAXS数据,可以提取不同尺寸的蛋白质种类的三维形状包络等结构信息。

SAXS非常适用于分析溶液中的蛋白质

在高通量条件下可获得蛋白之间的相互作用,回转半径,折叠度,大小和形状,从而研究其结构,构象和胶体稳定性。

您还可以探索SAXS如何在药物和疫苗开发的各个阶段中,为研究、开发和质量控制做出贡献的相关信息。

想了解更多关于药物开发的知识吗?

Microgels

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Thorough investigation of oligomers during protein fibrillation

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High throughput protein envelope determination

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Protein structure resolution

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用X射线散射来进行新药研发和配方的研究

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了解科研人员如何使用Xenocs仪器来进行研究和发布文章

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
Parra-Ortiz, E.; Browning, K.L.; Damgaard, L. S. E.; Nordström, R.; Micciulla, S.; Bucciarelli, S.; Malmsten, M.
Journal of Colloid and Interface Science2019
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences2017

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Nano-inXider

智能化纳米尺度表征

Protein Structure Analysis

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新一代实验室用(GI-)SAXS/WAXS/USAXS线站

BioXolver

助力您的生物结构研究

SAXS

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Protein Structure Analysis

蛋白质结构分析

蛋白质结构分析- 在实验室中得到蛋白质在溶液中的形状和动态行为

蛋白质结构分析- 在实验室中得到蛋白质在溶液中的形状和动态行为,在其天然环境中进行表征和研究。