Lipid Nanoparticles (LNPs) have attracted considerable attention as promising drug carriers due to their biocompatibility and ability to encapsulate...
emmeline.gaudard@xenocs.com18 January 2024
应用手册
The structural evolution of cellulose nanocrystals under shear is monitored using two different SAXS set-ups In the last two decades, bio-based nanomaterials have attracted increasing research interest for applications in a multitude of industrial sectors. Moreover, with soaring oil prices and the rising consumer appeal toward sustainable products, market growth…
emmeline.gaudard@xenocs.com9 May 2023
The structural evolution of P123 Pluronics was monitored and analyzed through shearSAXS measurements performed with the Xenocs Couette stage Poloxamers, also known under commercial names as Pluronics®, Synperonics® or Kolliphor® are a class of synthetic triblock copolymers that are composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) blocks. They…
emmeline.gaudard@xenocs.com9 May 2023
Investigation of smectite suspension shear behavior through SAXS measurements performed with the Xenocs Couette stage Clay minerals are a group of hydrous aluminosilicate minerals that are commonly found in soils, sediments, and rocks. The most common types include kaolinite, illite, and smectite, each with its own distinct characteristics and uses.…
emmeline.gaudard@xenocs.com9 May 2023
In this Application Note, the XSACT software package is used to process the SAXS data and determine the specific surface area of SiO2 powder samples. Both the invariant and the absolute-scale methods are employed, and the results are compared with the obtained from BET measurements and analysis.
emmeline.gaudard@xenocs.com12 January 2023
SAXS was used to study the effect of pH and protein concentration on the self-interaction process of a BSA system in solution Bovine serum albumin (BSA) is a non-glycosylated globular protein found in bovines. It is widely used in drug delivery, immunodiagnostic procedures and in clinical chemistry due to its…
emmeline.gaudard@xenocs.com5 January 2023
Residual stress analysis and texture measurements obtained on thin film samples with the interchangeable auxiliary source (AuX source) of the Xeuss 3.0.
Marie22 September 2022
Silks are well known natural protein fibers, spun by spiders, silkworms and other insects, that have been used for centuries in the textile industry due to...
Marie1 September 2022
Bovine serum albumin (BSA) is a non-glycosylated globular protein found in bovines. It is widely used in drug delivery, immunodiagnostic procedures and in clinical chemistry due to its low cost and...
Marie30 June 2022
Cocoa butter is a highly polymorphic compound exhibiting up to six crystalline forms of glycerides (fatty acids), each defined by different stability and melting point. In order to...
Marie12 April 2022
Time-resolved Small Angle X-ray Scattering (SAXS) mesurements, performed during synthesis procedures or other chemical or physical reactions, have the potential to reveal valuable information which can...
Marie16 March 2022
SAXS laboratory instruments provide traceable number concentration measurements for nanoparticles. Nanoparticles (NPs) are an essential building block for ...
Marie13
一月 2021
Size distributions of industrial nanoparticles have been determined in various forms for quality assessment and process monitoring. Nanoparticles are being produced at an increasing rate and have become an essential building block for the development of new materials with improved properties. The performance of the final products depends not only…
Marie25
六月 2019
Probing the effect of oxidation on model lipid bilayers. The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such…
Marie25
六月 2019
Screening of stimuli-responsive colloidal particles. Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing triggered release of encapsulated bioactive molecules. They additionally protect these loaded…
Marie18
六月 2019
The transient nature of aggregates during the fibrillation process of α-synuclein is highlighted with in-house SAXS experiments using the BioXolver. Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the…
Marie19
三月 2019
SAXS data and 3D envelopes of small and large protein species are obtained through in-line gel filtration. Small-angle X-ray scattering (SAXS) is commonly used to investigate the solution structure of biological macromolecules. Highly accurate results can be obtained with monodisperse solutions devoid of aggregates and impurities. Many biological processes, however,…
Marie19
三月 2019
Salt concentration and pH impact were studied on lysozyme and BSA systems respectively by investigating various parameters (osmotic second virial coefficient, folding state and 3D shape). Protein-protein interactions are relevant for various biological processes, such as transcription and signal transduction, but also for protein crystallization, stability and shelf-life of pharmaceutical…
Marie19
三月 2019
3D envelopes were determined from an automated sequence of measurements including 3 different proteins with low volume and dilute solutions. Small-angle X-ray scattering is complementary to other structural biology techniques. It provides reliable information on the shape of proteins in solution and associated parameters including macromolecule interactions and dynamics. Reliability of the…
Marie14
三月 2019
Shape and size of gold nanoparticles (NPs) in suspension have been determined by SAXS measurement. NPs are used even at very low concentration in many applications such as coatings, cosmetics or drug delivery. The performance of the final product depends not only on the chemical nature of the NPs but…
Marie31
一月 2019
SAXS investigations of Lysozyme solutions were performed enabling the calculation of the radius of gyration (Rg) and of the Pair-distance Distribution Function (PDDF). The Small Angle X-ray Scattering (SAXS) technique is now well known for studying biological systems and more specifically protein solutions. SAXS measurements allow the determination of the…
Marie31
一月 2019
Simultaneous SAXS/WAXS measurements of a semi-crystalline polymer during thermal processing enables determination of route for phase transformation. It is well known that polymers undergo a large series of thermal transformations, from the synthesis in the reactor up to the final product shaping, i.e. during injection molding processing or film formation.…
Marie18
十二月 2018
SAXS/WAXS measurements were performed on the Head & Shoulders Classic Clean Shampoo from Procter & Gamble and reveal its inner structure. Many personal care products are concentrated surfactant systems displaying a multi-phasic microstructure. To design new properties through innovative formulation and to control the latter during the production process, good…
Marie6
十二月 2018
Shape and size of gold nanoparticles (NPs) in suspension have been determined by SAXS measurement. NPs are used even at very low concentration in many applications such as coatings, cosmetics or drug delivery. (more…)
Marie21
十一月 2018
SAXS/WAXS measurements enable the determination of the characteristic dimensions and the semi-crystalline structure of Bombyx mori cocoon silk fibers. The excellent mechanical properties of silk fibers made them of great practical interest. However, relations between the macromolecular structure and the functional properties are far from being understood. More specifically hierarchical…
Marie21
十一月 2018
SAXS/WAXS investigation of the protein Sub-unit F of the eukaryotic V1V0 ATPase was performed using the Xeuss 2.0 SAXS/WAXS system, leading to its structure resolution. The Small-angle X-ray Scattering (SAXS) technique is now well known for studying biological systems and more specifically proteins in solution. SAXS measurements allow the determination…
Marie21
十一月 2018
Low polyolefin crystallinity fraction down to 0.3 % was determined during a kinetic experiment using the Xeuss 2.0 SAXS/WAXS system in combination with an integrated temperature control stage, the Linkam HFSX350. Mechanical and physical properties of solid polymers are resulting from its crystallization kinetic which affects both the nanoscale structure…
Marie21 November 2018
Application Note - AN-XE01 The level of crystallinity of a polyolefin was determined during a kinetic experiment using the Xeuss 2.0 SAXS/WAXS system in combination with an integrated temperature control stage, the Linkam HFSX350. Most polymer transformations from raw material to a finished product necessitate a processing step involving a…
Marie21 November 2018
