新药研发和配方

通过更加深入地了解蛋白质、抗体或大分子复合物在溶液中的复杂形状信息,从而加速您的药物研发过程,同时也适用于柔性和无序的蛋白质。

生物小角技术是提高您药物配方研究的有利工具,从而可获得宝贵的开发时间:

  • 有关现配的浓缩和稀释溶液中蛋白质相互作用的信息
  • 对低聚反应的高灵敏度
  • 可提高长期稳定性预测的构象和结构变化信息

监测并比较脂质药物传递系统在原料,挤压脂质体和药物产品的相变。

实验室SEC-SAXS联用可用于复杂样品的结构研究

在本应用实例中,通过在线凝胶过滤获得了足够高质量的SAXS数据,可以提取不同尺寸的蛋白质种类的三维形状包络等结构信息。

SAXS非常适用于分析溶液中的蛋白质

在高通量条件下可获得蛋白之间的相互作用,回转半径,折叠度,大小和形状,从而研究其结构,构象和胶体稳定性。

您还可以探索SAXS如何在药物和疫苗开发的各个阶段中,为研究、开发和质量控制做出贡献的相关信息。

想了解更多关于药物开发的知识吗?

SAXS as a tool for characterizing monoclonal antibody-protein antigen interactions

Detailed biophysical description of antibody-protein antigens interactions is important for guiding physical characterization and molecular engineering of therapeutic targets. Proteins can […]

Microgels

Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing […]

Vesicles

The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such as […]

Thorough investigation of oligomers during protein fibrillation

Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the adverse effects are not mature fibrils, but oligomers. These are aggregates formed transiently at […]

High throughput protein envelope determination

Small-angle X-ray scattering is complementary to other structural biology techniques. It provides reliable information on the shape of proteins in solution and associated parameters including macromolecule interactions and dynamics. Reliability of the measurements and high throughput are […]

Protein structure resolution

The Small-angle X-ray Scattering (SAXS) technique is now well known for studying biological systems and more specifically proteins in solution.
SAXS measurements allow the determination of the […]

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用X射线散射来进行新药研发和配方的研究

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了解科研人员如何使用Xenocs仪器来进行研究和发布文章

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
Parra-Ortiz, E.; Browning, K.L.; Damgaard, L. S. E.; Nordström, R.; Micciulla, S.; Bucciarelli, S.; Malmsten, M.
Journal of Colloid and Interface Science2019
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Kulkarni, P.; Jolly, M. K.; Jia, D.; Mooney, S. M.; Bhargava, A.; Kagohara, L. T.; Chen, Y.; Hao, P.; He, Y.; Veltri, R. W.; Grishaev, A.; Weninger, K.; Levine, H.; Orban, J.
Proceedings of the National Academy of Sciences2017

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我们的下列仪器可服务于您的新药研发和配方的研究

Nano-inXider

智能化纳米尺度表征

Protein Structure Analysis

Xeuss 3.0

新一代实验室用(GI-)SAXS/WAXS/USAXS线站

BioXolver

助力您的生物结构研究

SAXS

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Protein Structure Analysis

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Protein Structure Analysis

蛋白质结构分析

蛋白质结构分析- 在实验室中得到蛋白质在溶液中的形状和动态行为

蛋白质结构分析- 在实验室中得到蛋白质在溶液中的形状和动态行为,在其天然环境中进行表征和研究。