新药研发和配方
生物小角技术是提高您药物配方研究的有利工具，从而可获得宝贵的开发时间：
- 有关现配的浓缩和稀释溶液中蛋白质相互作用的信息
- 对低聚反应的高灵敏度
- 可提高长期稳定性预测的构象和结构变化信息
监测并比较脂质药物传递系统在原料，挤压脂质体和药物产品的相变。
SAXS非常适用于分析溶液中的蛋白质
在高通量条件下可获得蛋白之间的相互作用，回转半径，折叠度，大小和形状，从而研究其结构，构象和胶体稳定性。
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SAXS as a tool for characterizing monoclonal antibody-protein antigen interactions
Detailed biophysical description of antibody-protein antigens interactions is important for guiding physical characterization and molecular engineering of therapeutic targets. Proteins can […]
Microgels
Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing […]
Vesicles
The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such as […]
Thorough investigation of oligomers during protein fibrillation
Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the adverse effects are not mature fibrils, but oligomers. These are aggregates formed transiently at […]
High throughput protein envelope determination
Small-angle X-ray scattering is complementary to other structural biology techniques. It provides reliable information on the shape of proteins in solution and associated parameters including macromolecule interactions and dynamics. Reliability of the measurements and high throughput are […]
Protein structure resolution
The Small-angle X-ray Scattering (SAXS) technique is now well known for studying biological systems and more specifically proteins in solution.
SAXS measurements allow the determination of the […]
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用X射线散射来进行新药研发和配方的研究
